Disruption of mitochondrial oxidative phosphorylation by chidamide eradicates leukemic cells in AML.

Jun-Dan WangJue-Qiong XuZi-Jie LongJian-Yu Weng

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2023)

Chidamide disrupted mitochondrial OXPHOS, promoted cell apoptosis and reduced inflammation in AML cells. These findings exhibited a novel mechanism that targeting OXPHOS would be a novel strategy for AML treatment.

Keyphrases

acute myeloid leukemia
induced apoptosis
oxidative stress
cell cycle arrest
allogeneic hematopoietic stem cell transplantation
cell proliferation
endoplasmic reticulum stress
cell death
signaling pathway
drug delivery
cancer therapy
replacement therapy