Effects of a gestational level of estradiol on cellular transition, migration, and inflammation in cervical epithelial and stromal cells.

Ourlad Alzeus Gaddi TantengcoLauren S RichardsonRamkumar Menon

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2020)

Collectively, these results show that third trimester levels of E2 may permit localized inflammation, increase MMP-9 production, and cause an EMT-mediated impairment of the remodeling process in the cervix in vitro. These data suggest a potential contribution of E2 in cervical ripening.

Keyphrases

oxidative stress
preterm birth
weight gain
epithelial mesenchymal transition
electronic health record
big data
gestational age
body mass index
birth weight
risk assessment
physical activity
human health
weight loss