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Genetic Polymorphisms and Correlation with Treatment-Induced Cardiotoxicity and Prognosis in Patients with Breast Cancer.

Parvin F PeddiPeter Andreas FaschingDuan LiuEmmanuel QuinauxNicholas J RobertVicente ValeroJohn CrownCarla I FalksonAdam M BrufskyJulie M CunninghamRichard M WeinshilboumTadeusz PienkowskiWolfgang EiermannMiguel MartinValerie BeeXiaoyan WangLiewei WangEric H YangDennis J SlamonSara A Hurvitz
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
In the largest study to date to evaluate whether two polymorphisms are associated with DFS and/or cardiac toxicity in HER2-positive breast cancer treated with trastuzumab and/or anthracyclines, we observed no correlation.
Keyphrases
  • positive breast cancer
  • oxidative stress
  • diabetic rats
  • high glucose
  • left ventricular
  • combination therapy
  • metastatic breast cancer
  • tyrosine kinase
  • smoking cessation
  • early breast cancer
  • oxide nanoparticles