Genome-wide association study identifies high-impact susceptibility loci for HCC in North America.
Manal M HassanDonghui LiYounghun HanJinyoung ByunRikita I HatiaErping LongJiyeon ChoiRobin Kate KelleySean P ClearyAnna S LokPaige BracciJennifer B PermuthRoxana BucurJian-Min YuanAmit G SingalPrasun K JalalR Mark GhobrialRegina M SantellaYuko KonoDimpy P ShahMindie H NguyenGeoffrey LiuNeehar D ParikhRichard KimHui-Chen WuHashem El-SeragPing ChangYanan LiYun Shin ChunSunyoung S LeeJian GuErnest HawkRyan SunChad HuffAsif RashidHesham M AminLaura BerettaRobert A WolffSamuel O AntwiYehuda PattLu-Yu HwangAlison P KleinKaren ZhangMikayla A SchmidtDonna L WhiteJohn A GossSaira A KhaderiJorge A MarreroFrancisco G CigarroaPankil K ShahAhmed O KasebLewis R RobertsChristopher I AmosPublished in: Hepatology (Baltimore, Md.) (2024)
Our GWAS highlights novel genetic susceptibility of nonviral HCC among European descent populations from North America with substantial heritability. Selected genetic influences were observed for HCV-positive HCC. Our findings indicate the importance of genetic susceptibility to HCC development.