The impact of single nucleotide polymorphisms in ADORA2A and ADORA3 genes on the early response to methotrexate and presence of therapy side effects in children with juvenile idiopathic arthritis: Results of a preliminary study.
Justyna RoszkiewiczDominika A MichalekAleksandra RykZbigniew SwachaBartosz M SzmydElżbieta SmolewskaPublished in: International journal of rheumatic diseases (2020)
Although future studies are needed to verify our findings, polymorphisms in ADORA2A and ADORA3 genes may become the determinants of MTX treatment efficacy and gastrointestinal toxicity in children with JIA.