Overexpression of heat-shock protein 47 impacts survival of patients with oral squamous cell carcinoma.

Bruno Cesar da Costa Mauricio Rocha Dourado Everton Freitas de MoraisLuana Marí PaniniAmr ElseragyFábio Haach TéoGustavo Narvaes Guimarães Renato Assis MachadoMaija RisteliClarissa Araújo Gurgel RochaLívia Máris Ribeiro ParanaíbaWilfredo Alejandro González-ArriagadaSabrina Daniela da SilvaAna Lucia Carrinho Ayroza RangelMarcelo Rocha MarquesTuula SaloRicardo Della Coletta

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2023)

Our results show a significant prognostic impact of HSP47 overexpression in OSCC and reveal that HSP47 inhibition impairs the proliferation, migration, and invasion of OSCC cells. HSP47 may represent a potential therapeutic target for OSCC.

Keyphrases

heat shock protein
heat shock
induced apoptosis
cell proliferation
transcription factor
signaling pathway
cell cycle arrest
endoplasmic reticulum stress
single cell
gene expression
genome wide
oxidative stress
risk assessment