Foxf2 plays a dual role during transforming growth factor beta-induced epithelial to mesenchymal transition by promoting apoptosis yet enabling cell junction dissolution and migration.

Nathalie Meyer-SchallerChantal HeckStefanie TiedeMahmut YilmazGerhard Christofori

Published in: Breast cancer research : BCR (2018)

Our data identify the transcription factor Foxf2 as one of the important regulators of EMT, displaying a dual function in promoting tumor cell apoptosis as well as tumor cell migration.

Keyphrases

transforming growth factor
cell migration
epithelial mesenchymal transition
transcription factor
oxidative stress
single cell
cell proliferation
high glucose
cell death
cell therapy
stem cells
machine learning
big data
cell cycle arrest
pi k akt
artificial intelligence