External validation of a risk model predicting failure of salvage focal ablation for prostate cancer.
Alexander LightMax PetersDeepika ReddyAbi KanthabalanMarjorie OtienoMenelaos PavlouRumana OmarSola AdelekeFrancesco GigantiChris Brew-GravesNorman R WilliamsAmr EmaraAthar HaroonArash LatifoltojarHarbir SidhuAlex FreemanClément OrczykAshok NikapotaTim DudderidgeRichard G HindleyJaspal VirdiManit AryaHeather PayneAnita V MitraJamshed BomanjiMathias WinklerGail HoranCaroline M MooreMark EmbertonShonit PunwaniHashim Uddin AhmedTaimur T ShahPublished in: BJU international (2023)
In external validation using prospective, multicentre data, this model demonstrated modest discrimination but good calibration and clinical utility for predicting failure of salvage focal ablation within 2 years. This model could be reasonably used to improve selection of appropriate treatment candidates for salvage focal ablation, and its use should be considered when discussing salvage options with patients. Further validation in larger, international cohorts with longer follow-up is recommended.