Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr-/- Mice after Consumption of Guarana Soft Drinks.

Layla Aparecida ChistéBeatriz Peters PereiraMarcella Leite PortoJairo Pinto de OliveiraArícia Leone Evangelista Monteiro de AssisBreno Valentim NogueiraSilvana Santos MeyrellesTadeu Uggere de AndradeManuel Campos-ToimilElisardo Corral VasquezBianca Prandi Campagnaro Thiago Melo Costa Pereira

Published in: Oxidative medicine and cellular longevity (2019)

Chronic administration of GSD is prooxidative, compromising the cardiovascular, gastric, and hepatic systems; the effects are due at least in part to free sugar consumption but not to guarana extract per se.

Keyphrases

oxidative stress
dna damage
ischemia reperfusion injury
dna repair
induced apoptosis
high fat diet induced
metabolic syndrome
drug induced
type diabetes
signaling pathway
wild type
insulin resistance