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Gentulizumab, a novel anti-CD47 antibody with potent antitumor activity and demonstrates a favorable safety profile.

Tao WangSi-Qin WangYin-Xiao DuDan-Dan SunChang LiuShuang LiuYing-Ying SunHai-Long WangChun-Sheng ZhangHai-Long LiuLei JinXiao-Ping Chen
Published in: Journal of translational medicine (2024)
GenSci059 selectively binds to CD47, effectively blocks the CD47/SIRPα axis signaling pathway and enhances the phagocytosis effects of macrophages toward tumor cells. This monoclonal antibody demonstrates potent antitumor activity and exhibits a favorable safety profile, positioning it as a promising and effective therapeutic option for cancer.
Keyphrases
  • monoclonal antibody
  • signaling pathway
  • nk cells
  • papillary thyroid
  • anti inflammatory
  • squamous cell carcinoma
  • cell proliferation
  • oxidative stress
  • induced apoptosis