A novel FBW7/NFAT1 axis regulates cancer immunity in sunitinib-resistant renal cancer by inducing PD-L1 expression.

Wentao LiuDianyun RenWei XiongXin JinLiang Zhu

Published in: Journal of experimental & clinical cancer research : CR (2022)

Our data reveal a novel role for the FBW7/NFAT1 axis in the RCC response to TKIs and ICIs. NFAT1 and its associated signaling pathway might be therapeutic targets for RCC treatment, especially when combined with ICIs and/or TKIs.

Keyphrases

papillary thyroid
renal cell carcinoma
signaling pathway
squamous cell
nuclear factor
epithelial mesenchymal transition
squamous cell carcinoma
lymph node metastasis
immune response
single cell
genome wide
dna methylation
inflammatory response
artificial intelligence
combination therapy
smoking cessation