Drug-drug interactions with metronidazole and itraconazole in patients using acenocoumarol.

Matthijs L BeckerRenate C A E van UdenThijs J GiezenKarina MeijerIlse HoutenbosPatricia Maria Lucia Adriana van den Bemt

Published in: European journal of clinical pharmacology (2020)

Co-trimoxazole, metronidazole, and itraconazole increase the risk of overanticoagulation in patients using acenocoumarol. These combinations should be avoided if possible or otherwise acenocoumarol doses should be reduced and INR measured more frequently.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
emergency department