Simian hemorrhagic fever virus cell entry is dependent on CD163 and uses a clathrin-mediated endocytosis-like pathway.
Yingyun CaiElena N PostnikovaJohn G BernbaumShuiqing YuSteven MazurNicole M DeiuliisSheli R RadoshitzkyMatthew G LackemeyerAdam McCluskeyPhillip J RobinsonVolker HauckeVictoria Wahl-JensenAdam L BaileyMichael LauckThomas C FriedrichDavid H O'ConnorTony L GoldbergPeter B JahrlingJ Thomas BeattyPublished in: Journal of virology (2014)
Simian hemorrhagic fever virus (SHFV) causes highly lethal disease in Asian macaques resembling human illness caused by Ebola or Lassa virus. However, little is known about SHFV's ecology and molecular biology and the mechanism by which it causes disease. The results of this study shed light on how SHFV enters its target cells. Using electron microscopy and inhibitors for various cellular pathways, we demonstrate that SHFV invades cells by low-pH-dependent, actin-independent endocytosis, likely with the help of a cellular surface protein.