Proanthocyanidin enhances the endogenous regeneration of alveolar bone by elevating the autophagy of PDLSCs.

Zhuo LiuQilin LiXiangyao WangYaxin WuZhixing ZhangJing MaoShiqiang Gong

Published in: Journal of periodontal research (2023)

PA may activate autophagy by inhibiting PI3K/Akt/mTOR signaling pathway to promote the osteogenesis of PDLSCs and enhance endogenous alveolar bone regeneration.

Keyphrases

bone regeneration
signaling pathway
pi k akt
induced apoptosis
epithelial mesenchymal transition
cell death
endoplasmic reticulum stress
stem cells
oxidative stress
bone mineral density
wound healing
body composition