Intragenic sequences in the trophectoderm harbour the greatest proportion of methylation errors in day 17 bovine conceptuses generated using assisted reproductive technologies.

Alan Mark O'DohertyPaul McGettiganRachelle E IrwinDavid A MageeDominic GagneEric FournierAbdullah Al-NaibMarc-André SirardColum P WalshClaude RobertTrudee Fair

Published in: BMC genomics (2018)

By examining (1) the effects of superovulation and (2) the effects of an in vitro system (oocyte maturation, fertilisation and embryo culture) we have identified that the assisted reproduction process of superovulation alone has the largest impact on the DNA methylome of subsequent embryos.

Keyphrases

circulating tumor
cell free
dna methylation
single molecule
genome wide
patient safety
adverse drug
emergency department
gene expression