MMP-13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation.
Joanna-Marie HowesNicholas PughSamir W HamaiaStephanie M JungVera KnäuperJean-Daniel MalcorRichard W FarndalePublished in: Research and practice in thrombosis and haemostasis (2018)
Our data demonstrate a role for MMP-13 in the inhibition of both platelet aggregation and thrombus formation in whole flowing blood, and may provide new avenues of research into the mechanisms underlying the subtle role of MMP-13 in atherothrombotic pathologies.
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