Inhibitory effect of baricitinib on microglia and STAT3 in a region with a weak blood-brain barrier in a mouse model of rheumatoid arthritis.
Takayuki MatsushitaKazuhiro OtaniMasayuki YoshigaMasashi HiranoKentaro NodaDaitaro KurosakaPublished in: Rheumatology (Oxford, England) (2023)
Our results demonstrate that baricitinib can affect brain cells, specifically microglia, in the brain region with a weak BBB and mitigate aberrant behaviors during autoimmune arthritis, pointing to the potential therapeutic effect of JAKi on brain pathologies underpinning RA.
Keyphrases
- blood brain barrier
- rheumatoid arthritis
- cerebral ischemia
- resting state
- white matter
- mouse model
- functional connectivity
- inflammatory response
- disease activity
- induced apoptosis
- neuropathic pain
- multiple sclerosis
- cell proliferation
- interstitial lung disease
- cell cycle arrest
- systemic sclerosis
- idiopathic pulmonary fibrosis