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Palatal Soft Tissue Myxoma in a Patient with Carney Complex.

Bruno Augusto Linhares Almeida MarizElena María José Román TagerCarlos Cordón FernandezOslei Paes de AlmeidaRoman Carlos
Published in: Head and neck pathology (2020)
Carney complex (CNC) is a rare, autosomal dominant multiple neoplasia syndrome. Although cutaneous myxomas commonly occur in CNC patients, intraoral myxomas are extremely rare. We present a case of a palatal myxoma in a 21-year-old female patient with CNC, along with a review of the pertinent literature. She presented with a sessile nodule on the hard palate that microscopically showed a multilobulated and highly vascularized myxomatous tissue composed of loosely-arranged spindle, polygonal, and stellate cells, suggestive of myxoid neurofibroma. Six years after the oral lesion was removed, she presented with a growth hormone (GH)-producing pituitary adenoma, a cardiac myxoma, two cutaneous myxomas on the lower abdomen area, and one myxoma in the vaginal mucosa. Therefore, the final diagnosis of the palatal lesion was of a soft tissue myxoma related to CNC. The patient remains on close follow-up, with no recurrences of the palatal myxoma after 7 years.
Keyphrases
  • growth hormone
  • soft tissue
  • case report
  • systematic review
  • induced apoptosis
  • newly diagnosed
  • cell cycle arrest
  • high grade
  • oxidative stress
  • heart failure
  • cell proliferation
  • patient reported
  • drug induced