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Pro-inflammatory feedback loops define immune responses to pathogenic Lentivirus infection.

Aaron J WilkJoshua O MarceauSamuel W KazerIra FlemingVincent N MiaoJennyfer Galvez-ReyesJason T KimataAlex K ShalekSusan HolmesJulie OverbaughCatherine A Blish
Published in: Genome medicine (2024)
Our work presents a model of lentiviral pathogenicity where failures in early viral control mechanisms lead to delayed, sustained, and amplifying pro-inflammatory circuits, which in turn drives disease progression.
Keyphrases
  • immune response
  • sars cov
  • fluorescent probe
  • sensitive detection
  • gene therapy
  • living cells
  • dendritic cells
  • biofilm formation
  • escherichia coli
  • staphylococcus aureus
  • cystic fibrosis
  • quantum dots