CRY2 mediates the cognitive decline induced by sleep deprivation in 5xFAD mice.

Sumei LuoLizhe GuoNa ChenQulian GuoYongqiu XieYunjiao WangE Wang

Published in: PloS one (2024)

Our study demonstrated that sleep deprivation upregulated CRY2 in the hippocampus of AD mice, which resulted in synaptic dysfunction by decreasing CISH-mediated STAT1 phosphorylation.

Keyphrases

cognitive decline
mild cognitive impairment
high fat diet induced
sleep quality
physical activity
cell proliferation
type diabetes
metabolic syndrome
wild type
depressive symptoms
brain injury