Transcriptional profiling of Toll-like receptor 2-deficient primary murine brain cells during Toxoplasma gondii infection.
Kousuke UmedaSachi TanakaFumiaki IharaJunya YamagishiYutaka SuzukiYoshifumi NishikawaPublished in: PloS one (2017)
To our knowledge, this is the first transcriptomic study of TLR2 function across different cell types during T. gondii infection. Results of RNA-sequencing demonstrated roles for TLR2 varied by cell type during T. gondii infection. Our findings facilitate understanding of the detailed relationship between TLR2 and T. gondii infection, and elucidate mechanisms underlying neurological changes during infection.
Keyphrases
- toll like receptor
- inflammatory response
- single cell
- immune response
- nuclear factor
- toxoplasma gondii
- healthcare
- stem cells
- gene expression
- oxidative stress
- induced apoptosis
- multiple sclerosis
- rna seq
- cell death
- white matter
- signaling pathway
- functional connectivity
- cell proliferation
- resting state
- brain injury
- pi k akt
- heat stress
- blood brain barrier
- endoplasmic reticulum stress