Outcome of cancer-related seizures in patients treated with lacosamide.

M ToledoA MolinsM QuintanaE SantamarinaF Martinez-RicarteE Martínez-SaezJ Salas-Puig

Published in: Acta neurologica Scandinavica (2017)

Lacosamide is an AED to consider in cases of cancer-related seizures. Lacosamide pharmacodynamics and pharmacokinetics allow the achievement of responder rates over 50% with no serious adverse effects, amelioration of side effects from other AEDs or radio-/chemotherapy, and no significant drug interactions. Furthermore, the intravenous formulation shows clear benefits in acute conditions such as status epilepticus.

Keyphrases

liver failure
drug delivery
high dose
respiratory failure
locally advanced
aortic dissection
squamous cell carcinoma
low dose
rectal cancer
acute respiratory distress syndrome