Genetically engineered macrophages persist in solid tumors and locally deliver therapeutic proteins to activate immune responses.
Katherine J BrempelisCourtney M CowanShannon A KreuserKevin P LabadieBrooke M PrieskornNicole A P LiebermanChibawanye I EneKara W MoyesHarrison ChinnKole R DeGolierLisa R MatsumotoSara K DanielJason K YokoyamaAmira D DavisVirginia J HoglundKimberly S SmytheStephanie D BalcaitisMichael C JensenRichard G EllenbogenJean S CampbellRobert H PierceEric C HollandVenu G PillarisettyCourtney A CranePublished in: Journal for immunotherapy of cancer (2021)
Our data demonstrate that GEMs can precisely deliver titratable doses of therapeutic proteins to the TME to improve safety, tissue penetrance, targeted delivery and pharmacokinetics.