The role of c-Jun for beating cardiomycyte formation in prepared embryonic body.

Lide SuGuofu ZhangLili JiangChao ChiBing BaiKai Kang

Published in: Stem cell research & therapy (2023)

Knocking out c-Jun directs ESCs toward a meso-endodermal cell lineage fate, in turn leading to generation of beating myocardial cells. Thus, c-Jun plays an important role in regulating early cardiac cell development.

Keyphrases

single cell
left ventricular
cell therapy
induced apoptosis
cell cycle arrest
heart failure
mesenchymal stem cells
bone marrow
signaling pathway
single molecule
cell fate