Spatiotemporal characteristics of neurophysiological changes in patients with four-repeat tauopathies.
Niyatee SamudraHannah LernerLeslie YackChristine M WalshHeidi E KirschKiwamu KudoClaire YballaRenaud La JoieMaria L Gorno-TempiniSalvatore SpinaWilliam W SeeleyThomas C NeylanBruce L MillerGil D RabinoviciAdam BoxerLea T GrinbergKatherine P RankinSrikantan S NagarajanKamalini G RanasinghePublished in: Annals of clinical and translational neurology (2024)
Alpha power increase in PSP-tauopathy and reduction in the presence of AD-tauopathy is consistent with the observation that neurons activating wakefulness-promoting systems are preserved in PSP but degenerated in AD. These results highlight the selectively vulnerable impacts in 4RT versus AD-tauopathy that may have translational significance on disease-modifying therapies for specific proteinopathies.