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Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes.

Fatemeh MoadabSepideh SohrabiXiaoxing WangRayan NajjarJustina C WoltersHua JiangWenyan MiaoDonna RomeroDennis M ZallerMegan TranAlison BaysMartin S TaylorRosana KapellerJohn LaCavaTomas Mustelin
Published in: Mobile DNA (2024)
These results bring new insights into the composition of ORF1p granules in SLE neutrophils and may explain, in part, why proteins in these granules become targeted by autoantibodies in this disease.
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