Identification and characterization of the new generation sGC stimulator BAY 1165747 (BAY-747) designed for the treatment of resistant hypertension.

BAY-747 is a potent, orally available sGC stimulator. BAY-747 shows long-acting pharmacodynamic effects with a very low peak-to-trough ratio. BAY-747 could be a treatment alternative for patients with hypertension, especially those not responding to standard of care therapy.