Roux-en-Y gastric bypass surgery restores insulin-mediated glucose partitioning and mitochondrial dynamics in primary myotubes from severely obese humans.
Benjamin A KuglerAnders E GundersenJunhan LiWenqian DengNancy EugenePhilimon N GonaJoseph A HoumardKai ZouPublished in: International journal of obesity (2005) (2019)
These data indicate that an intrinsic metabolic defect of glucose partitioning in skeletal muscle from severely obese humans is restored by RYGB surgery. The restoration of glucose partitioning may be regulated through reduced mitochondrial fission protein Drp1 phosphorylation.
Keyphrases
- roux en y gastric bypass
- weight loss
- obese patients
- minimally invasive
- gastric bypass
- skeletal muscle
- bariatric surgery
- coronary artery bypass
- type diabetes
- blood glucose
- oxidative stress
- adipose tissue
- glycemic control
- metabolic syndrome
- surgical site infection
- insulin resistance
- electronic health record
- blood pressure
- percutaneous coronary intervention
- binding protein
- small molecule
- protein kinase
- machine learning
- deep learning
- protein protein