Extracellular CIRP induces CD4CD8αα intraepithelial lymphocyte cytotoxicity in sepsis.

Yuichi AkamaAtsushi MuraoMonowar Aziz Ping Wang

Published in: Molecular medicine (Cambridge, Mass.) (2024)

In sepsis, the cytotoxicity initiated by the eCIRP/TLR4 axis in CD4CD8αα IELs is associated with intestinal epithelial cell (IEC) death, which could lead to gut injury.

Keyphrases

septic shock
acute kidney injury
intensive care unit
high grade
toll like receptor
inflammatory response
immune response