Demographic and clinical characteristics of patients with metastatic breast cancer and leptomeningeal disease: a single center retrospective cohort study.

Laura A HuppertSamantha FischElene TsopurashviliSai Sahitha SomepalleMia SalansHarish N VasudevanA Jo ChienMelanie MajureHope S RugoRonald BalassanianLauren BoretaMichelle E Melisko

Published in: Breast cancer research and treatment (2024)

This is one of the largest case series of patients with MBC and LMD. Patients diagnosed with LMD from 2015 to 2024 lived longer than those diagnosed from 2000 to 2014, although median OS was short overall. Patients with TNBC and LMD had particularly short OS. Novel therapeutic strategies for LMD remain an area of unmet clinical need.

Keyphrases

metastatic breast cancer
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
small cell lung cancer
patient reported outcomes