Acute toxicity and effects of Roundup Original® on pintado da Amazônia.
Jhonnes Marcos Dos Santos TeixeiraValfran da Silva LimaFernando Rafael de MouraPatrícia da Costa MariscoValéria Dornelles Gindri SinhorinValéria Dornelles Gindri SinhorinPublished in: Environmental science and pollution research international (2018)
The toxicity of Roundup Original® (GLY), a glyphosate-based herbicide widely used in crops in Mato Grosso state, was determined in hybrid fish jundiara or pintado da Amazônia. The 96 h-LC50 of GLY was 13.57 mg L-1. Moreover, exposure to sublethal concentrations of GLY (0, 0.37, 0.75, 2.25, 4.5, 7.5 mg L-1) has not altered the survival rate (100% for all treatments). In fish liver, protein carbonyl (PC) levels as well as glutathione-S-transferase (GST) activity, reduced glutathione (GSH), and ascorbic acid (ASA) contents increased when compared to control group. Superoxide dismutase (SOD) activity was reduced and catalase (CAT) has not changed. PC content has grown in muscle and brain, and thiobarbituric acid-reactive species (TBARS) levels also increased in muscle, but in the brain, they remained unaltered. Acetylcholinesterase (AChE) activity reduced in muscle but increased in brain when compared to control group. Our results suggest that short-term exposure to GLY induced alterations in the oxidative stress biomarkers in fish and can be interfering with their survival in natural environment; besides, these findings may be considered of high ecotoxicological relevance.
Keyphrases
- oxidative stress
- resting state
- white matter
- skeletal muscle
- functional connectivity
- cerebral ischemia
- dna damage
- liver failure
- drug induced
- hydrogen peroxide
- ischemia reperfusion injury
- respiratory failure
- nitric oxide
- induced apoptosis
- simultaneous determination
- acute respiratory distress syndrome
- endoplasmic reticulum stress