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Accuracy of iodine density thresholds for the separation of vertebral bone metastases from healthy-appearing trabecular bone in spectral detector computed tomography.

Jan BorggrefeVictor-Frederic NeuhausMarkus Le BlancNils Grosse HokampVolker MausAnastasios MpotsarisSimon LennartzDaniel Pinto Dos SantosDavid MaintzNuran Abdullayev
Published in: European radiology (2018)
• SDCT iodine density mapping provides the possibility for quantitative analysis of iodine uptake in tissue, which allows to differentiate bone lesions from healthy bone marrow. • Age and vBMD have a significant impact on iodine density measurements. • Iodine density measured in SDCT yielded highest sensitivity and specificity for the statistical differentiation of vertebral trabecular metastases and healthy trabecular bone using an iodine density threshold of 4.5 mg/ml (most performant)-5.0 mg/ml (optimized for specificity).
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