The antiferroptotic role of TRIM7: Molecular mechanism and synergistic effect with temozolomide.

Luyao WangRongyang XuChengying HuangShanqiang Qu

Published in: Cancer innovation (2023)

Nuclear receptor coactivator 4 (NCOA4) protein is a selective cargo receptor that plays a crucial role in ferritinophagy by targeting and delivering the ferritin iron storage protein to lysosomes for degradation and releasing iron. TRIM7 overexpression inhibits ferroptosis in glioblastoma cells by ubiquitinating NCOA4 protein.

Keyphrases

protein protein
binding protein
amino acid
induced apoptosis
cell death
cell proliferation
small molecule
cell cycle arrest
transcription factor