Clinically actionable secondary findings in 130 triads from sub-Saharan African families with non-syndromic orofacial clefts.
Abimbola M OladayoLord Jephthah Joojo GowansWaheed AwotoyeAzeez Arisekola AladeTamara BuschThirona NaickerMekonen A EsheteWasiu Lanre AdeyemoJacqueline B HetmanskiErliang ZengOlawale AdamsonChinyere AdelekeMary LiVeronica SuleSami KayaliJoy OlotuPeter A MosseySolomon Obiri-YeboahCarmen J BuxoTerri BeatyMargaret TaubPeter DonkorMary L MarazitaOluwakemi OdukoyaAdebowale A AdeyemoJeffrey C MurrayAnya PrinceAzeez ButaliPublished in: Molecular genetics & genomic medicine (2023)
This study provides information on the frequency and pathogenicity of SFs in an African cohort. Early risk detection will help reduce disease burden and contribute to efforts to increase knowledge of the distribution and impact of actionable genomic variants in diverse populations.