Clinical Exome Gene Panel Analysis of a Cohort of Urothelial Bladder Cancer Patients from Sri Lanka.
Ajith Peiris MalalasekeraNilaksha NeththikumaraPraveenan SomasundaramSajeewani PathiranaChathumadavi EdiriweeraDileepa EdiriweeraSerozsha As GoonewardenaNeville D PereraAnuruddha AbeygunasekaraRohan W JayasekaraKalum WettasingheM Dilani S LokuhettyVajira H W DissanayekePublished in: Asian Pacific journal of cancer prevention : APJCP (2023)
Clinical exome sequencing utilising a gene panel yielded a high mutation rate in our patients. The predominant mutational change was C>T and G>A. Three clusters of genes were identified. SYNE1 was the gene with the most mutations. The mutations comprised predominantly of genes of the chromatin remodelling pathway.
Keyphrases
- genome wide
- copy number
- genome wide identification
- transcription factor
- end stage renal disease
- dna methylation
- genome wide analysis
- chronic kidney disease
- gene expression
- ejection fraction
- newly diagnosed
- single cell
- spinal cord injury
- dna damage
- patient reported outcomes
- peritoneal dialysis
- african american
- oxidative stress
- high grade