Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness - ENIGMA study in 2 436 individuals.
Sean R McWhinneyChristoph AbéMartin AldaFrancesco BenedettiErlend BøenCaterina Del Mar BonninTiana BorgersKatharina BroschErick J Canales-RodríguezDara M CannonUdo DannlowskiAna M Diaz-ZuluagaLorielle DietzeTorbjørn ElvsåshagenLisa T EylerJanice M FullertonJose M GoikoleaJanik GoltermannDominik GrotegerdBartholomeus Cm 'Benno' HaarmanTim HahnFleur M HowellsMartin IngvarTilo T J KircherAxel KrugRayus T KuplickiMikael LandénHannah LemkeBenny LibergCarlos Lopez-JaramilloUlrik F MaltFiona M MartynElena MazzaColm McDonaldGenevieve McPhilemySandra MeierSusanne MeinertTina MellerElisa M T MelloniPhilip B MitchellLeila NabulsiIgor NenadićNils OpelRoel A OphoffBronwyn J OversJulia-Katharina PfarrJulian A Pineda-ZapataEdith Pomarol-ClotetJoaquim RaduàJonathan ReppleMaike RichterKai G RingwaldGloria RobertsAlex RossRaymond SalvadorJonathan SavitzSimon SchmittPeter R SchofieldKang SimDan J SteinFrederike SteinHenk S TemminghKatharina ThielSophia I ThomopoulosNeeltje E M van HarenHolly Van GestelCristian Vargas UpeguiEduard VietaAnnabel VreekerLena WaltemateLakshmi N YathamChristopher R K ChingOle AndreassenPaul M ThompsonTomas Hajeknull nullPublished in: Bipolar disorders (2021)
We provide evidence that both BD and obesity are associated with similar alterations in cortical thickness, but not surface area. The fact that obesity increased the chance of having low cortical thickness could explain differences in cortical measures among people with BD. The lower cortical thickness in individuals with higher BMI, which was additive and similar to the BD associated alterations, suggests that treating obesity could lower the extent of cortical thinning in BD.