Gender differences in patients with anti-MDA5-positive dermatomyositis: a cohort study of 251 cases.
Lu ChengLingxiao XuYan XuFenghong YuanJu LiMin WuZhanyun DaHua WeiLei ZhouSonglou YinJian WuYan LuDinglei SuZhichun LiuLin LiuLongxin MaXiaoyan XuHuijie LiuTianli RenYinshan ZangPublished in: Clinical rheumatology (2023)
DM exhibit an increased risk of RPILD, elevated mortality rates and reduced overall survival time compared to their female counterparts, and anti-Ro52 positivity may be an unfavorable prognostic factor for these patients. Key Points • The prevalence of solar rash, V sign, severe interstitial lung disease (ILD) and rapidly progressive interstitial lung disease (RPILD) in anti-MDA5-positive female patients was significantly lower than that in male patients. • Positive Anti-Ro52, high CRP level, and short course of disease were independent risk factors for RPILD in both men and women. • Female patients exhibited a lower mortality rate than male patients (22.0% vs 33.8%) and demonstrated longer survival time.
Keyphrases
- end stage renal disease
- prognostic factors
- interstitial lung disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- systemic sclerosis
- peritoneal dialysis
- multiple sclerosis
- risk factors
- patient reported outcomes
- type diabetes
- systemic lupus erythematosus
- idiopathic pulmonary fibrosis
- cell proliferation
- cardiovascular events
- skeletal muscle
- glycemic control