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Nitroglycerin-Citrate-Ethanol Catheter Lock Solution Is Highly Effective for In Vitro Eradication of Candida auris Biofilm.

Nylev Vargas-CruzRuth A ReitzelJoel RosenblattAnne-Marie ChaftariRita Wilson DibRay HachemDimitrios P KontoyiannisIssam I Raad
Published in: Antimicrobial agents and chemotherapy (2019)
Candida auris poses emerging risks for causing severe central line-associated bloodstream infections. We tested in vitro the ability of antifungal lock solutions to rapidly eradicate C. auris biofilms. Liposomal amphotericin B, amphotericin B deoxycholate, fluconazole, voriconazole, micafungin, caspofungin, and anidulafungin failed to completely eradicate all 10 tested C. auris biofilms. Conversely, nitroglycerin-citrate-ethanol (NiCE) catheter lock solution completely eradicated all replicates for all of C. auris biofilms tested.
Keyphrases
  • candida albicans
  • biofilm formation
  • staphylococcus aureus
  • cystic fibrosis
  • climate change
  • solid state
  • drug induced