Nitroglycerin-Citrate-Ethanol Catheter Lock Solution Is Highly Effective for In Vitro Eradication of Candida auris Biofilm.

Nylev Vargas-CruzRuth A ReitzelJoel RosenblattAnne-Marie ChaftariRita Wilson DibRay HachemDimitrios P KontoyiannisIssam I Raad

Published in: Antimicrobial agents and chemotherapy (2019)

Candida auris poses emerging risks for causing severe central line-associated bloodstream infections. We tested in vitro the ability of antifungal lock solutions to rapidly eradicate C. auris biofilms. Liposomal amphotericin B, amphotericin B deoxycholate, fluconazole, voriconazole, micafungin, caspofungin, and anidulafungin failed to completely eradicate all 10 tested C. auris biofilms. Conversely, nitroglycerin-citrate-ethanol (NiCE) catheter lock solution completely eradicated all replicates for all of C. auris biofilms tested.

Keyphrases

candida albicans
biofilm formation
staphylococcus aureus
cystic fibrosis
climate change
solid state
drug induced