The synergistic effect of Co/Ni in ultrathin metal-organic framework nanosheets for the prominent optimization of non-enzymatic electrochemical glucose detection.
Haihan ZouDongyan TianChao LvSongmei WuGuanxuan LuYifan GuoYubin LiuYu YuKejian DingPublished in: Journal of materials chemistry. B (2020)
Hybrid metal compounds have been paid increasing attention for the development of electroanalysis materials due to the specific collaboration interaction and synergy effect of metal elements. Herein, a series of ultrathin Ni/Co bimetallic metal-organic-framework nanosheets (UMOFNs) with different metal ratios were investigated as high-performance electroanalysis materials for non-enzymatic glucose electrochemical sensing. The synergistic effect between Ni/Co endowed UMOFNs with not only the unique electrochemical behavior that prompts the sensing-related electrochemical oxidation at a low applied potential, but also the enhanced affinity to glucose; also, they facilitated the electron transfer involving the analyte. The UMOFN composite with an elaborately adjusted Co/Ni ratio exhibits an extremely outstanding glucose sensing performance, including high sensitivity (2086.7 μA mM-1 cm-2), wide linear range (0.1 μM-1.4 mM), low detection limit (0.047 μM), and excellent selectivity. It can also be used for the detection of glucose in actual human serum samples with an accuracy of 90.1%, demonstrating a good application prospect of the non-enzymatic electrochemical glucose detection.
Keyphrases
- metal organic framework
- label free
- electron transfer
- gold nanoparticles
- blood glucose
- ionic liquid
- loop mediated isothermal amplification
- hydrogen peroxide
- molecularly imprinted
- real time pcr
- high resolution
- risk assessment
- nitric oxide
- insulin resistance
- weight loss
- tandem mass spectrometry
- single molecule
- high speed
- sensitive detection
- solid phase extraction
- liquid chromatography