Organ-specific extracellular matrix directs trans-differentiation of mesenchymal stem cells and formation of salivary gland-like organoids in vivo.

Olivia N TranHanzhou WangShengxian LiAndrey MalakhovYuyang SunParveez A Abdul AzeesAaron O GonzalezBrian CaoMilos MarinkovicBrij B SinghDavid D DeanChih-Ko Yeh Xiao-Dong Chen

Published in: Stem cell research & therapy (2022)

The results of this study suggest the feasibility of using autologous BM-MSCs as an abundant source of stem cells for treating SG hypofunction and restoring the production of saliva in these patients.

Keyphrases

mesenchymal stem cells
extracellular matrix
stem cells
end stage renal disease
cell therapy
umbilical cord
bone marrow
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
peritoneal dialysis
patient reported outcomes
platelet rich plasma