Hepatocyte leukotriene B4 receptor 1 promotes NAFLD development in obesity.

Xing-Feng LiuKai WangLuhai WangLijuan KongShaocong HouYanjun WanChunxiao MaJingwen ChenXiaowei XingCaiyi XingQian JiangQijin ZhaoBing CuiZhifeng Huang Ping-Ping Li

Published in: Hepatology (Baltimore, Md.) (2022)

LTB4/Ltb4r1 promotes hepatocyte lipogenesis directly by activating PKA-IRE1α-XBP1s to promote lipogenic gene expression. Inhibition of hepatocyte Ltb4r1 improved hepatic steatosis and insulin resistance. Ltb4r1 is a potential therapeutic target for NAFLD.

Keyphrases

insulin resistance
gene expression
high fat diet induced
liver injury
metabolic syndrome
type diabetes
adipose tissue
high fat diet
dna methylation
drug induced
skeletal muscle
weight loss
polycystic ovary syndrome
endoplasmic reticulum stress
weight gain
glycemic control