Sperm DNA integrity status is associated with DNA methylation signatures of imprinted genes and non-imprinted genes.

Bing SongChao WangYujie ChenGuanjian LiYang GaoFuxi ZhuHuan WuMingrong LvPing ZhouZhaolian WeiXiaojin HeYunxia Cao

Published in: Journal of assisted reproduction and genetics (2021)

In this study, we found that different site-specific DNA methylation signatures were correlated with sperm DNA integrity status. Further studies are needed to investigate the specific mechanisms leading to the epigenetic modifications.

Keyphrases

genome wide
dna methylation
circulating tumor
gene expression
copy number
cell free
single molecule
nucleic acid
bioinformatics analysis
genome wide identification
mass spectrometry