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NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's disease genetic and genomic knowledge.

Emily Greenfest-AllenOtto ValladaresPavel P KuksaPrabhakaran GangadharanWan-Ping LeeJeffrey CifelloZivadin KatanicAmanda B KuzmaNicholas WheelerWilliam S BushYuk Yee LeungGerard SchellenbergChristian J StoeckertLi-San Wang
Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
The National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) offers to the public a unique, disease-centric collection of AD-relevant GWAS summary statistics datasets. Interpreting these data is challenging and requires significant bioinformatics expertise to standardize datasets and harmonize them with functional annotations on genome-wide scales. The NIAGADS Alzheimer's GenomicsDB helps overcome these challenges by providing a user-friendly public knowledge base for AD-relevant genetics that shares harmonized, annotated summary statistics datasets from the NIAGADS repository in an interpretable, easily searchable format.
Keyphrases
  • healthcare
  • genome wide
  • cognitive decline
  • electronic health record
  • mental health
  • rna seq
  • dna methylation
  • copy number
  • big data
  • mild cognitive impairment
  • gene expression
  • quality improvement
  • adverse drug