Deep resequencing of the 1q22 locus in non-lobar intracerebral hemorrhage.

Livia ParodiMary E ComeauMarios K GeorgakisErnst MayerhoferJaeyoon Chung Guido J FalconeRainer MalikStacie L DemelBradford B WorrallSebastian KochFernando D TestaiSteven J KittnerJacob L McCauleyChristiana E HallDouglas J MaysonMitchell Sv ElkindMichael L JamesDaniel WooJonathan RosandCarl D LangefeldChristopher D Anderson

Published in: Annals of neurology (2023)

Altered promoter-enhancer interactions leading to PMF1 overexpression, potentially dysregulating polyamine catabolism, could explain demonstrated associations with non-lobar ICH risk at 1q22, offering a potential new target for prevention of ICH and CSVD. This article is protected by copyright. All rights reserved.

Keyphrases

transcription factor
brain injury
dna methylation
cell proliferation
gene expression
binding protein
human health
risk assessment
breast cancer risk