Atom-efficient arylation of N -tosylimines mediated by cooperative ZnAr 2 /Zn(C 6 F 5 ) 2 combinations.

Andryj M BorysTim KunzmannJose M Gil-NegreteEva Hevia

Published in: Chemical communications (Cambridge, England) (2023)

By combining the Lewis acid Zn(C 6 F 5 ) 2 with nucleophilic diarylzinc (ZnAr 2 ) reagents, we report the atom-efficient arylation of N -tosylimines under mild conditions. Mechanistic studies through the isolation of key intermediates reveal how the two zinc species act cooperatively to activate the imine substrate and regenerate the ZnAr 2 reagent, enabling a limiting 50 mol% to be employed.

Keyphrases

molecular dynamics
heavy metals
genome wide
electron transfer
single cell
case control
gene expression
genetic diversity