Interleukin-34 Reprograms Glycolytic and Osteoclastic Rheumatoid Arthritis Macrophages via Syndecan 1 and Macrophage Colony-Stimulating Factor Receptor.
Katrien Van RaemdonckSadiq UmarKarol PalasiewiczMichael V VolinHatem A ElshabrawyBianca RomayChandana TetaliAzam AhmedM Asif AminRyan K ZomorrodiNadera SweissShiva ShahraraPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
IL-34 is a novel endogenous factor that remodels hypermetabolic M34 macrophages and facilitates their cross-regulation with T effector cells to advance inflammatory bone destruction in RA.
Keyphrases
- rheumatoid arthritis
- induced apoptosis
- disease activity
- cell cycle arrest
- oxidative stress
- adipose tissue
- ankylosing spondylitis
- regulatory t cells
- bone mineral density
- dendritic cells
- endoplasmic reticulum stress
- soft tissue
- immune response
- cell death
- binding protein
- type iii
- body composition
- postmenopausal women
- pi k akt