Hippocampal network abnormalities explain amnesia after VGKCC-Ab related autoimmune limbic encephalitis.

Clare LoaneGeorgios P D ArgyropoulosAdriana Roca-FernándezCarmen LageFintan SheerinSamrah AhmedGiovanna ZamboniClare MackaySarosh R IraniChristopher R Butler

Published in: Journal of neurology, neurosurgery, and psychiatry (2019)

VGKCC-Ab-LE results in persistent isolated memory impairment. Patients have hippocampal atrophy with further reduced mediodorsal thalamic and posteromedial cortical volumes. Crucially, reduced FC of remaining hippocampal tissue correlates more closely with memory function than does regional atrophy.

Keyphrases

end stage renal disease
ejection fraction
cerebral ischemia
working memory
chronic kidney disease
multiple sclerosis
deep brain stimulation
patient reported outcomes
network analysis