FGFR1 Signaling Facilitates Obesity-Driven Pulmonary Outgrowth in Metastatic Breast Cancer.

Eylem Kulkoyluoglu Cotul Muhammad Hassan Safdar Sebastian Juan Paez Aneesha Kulkarni Mitchell G Ayers Hang Lin Zilin Xianyu Dorothy Teegarden Stephen D Hursting Michael K Wendt

Published in: Molecular cancer research : MCR (2024)

Overall, this study developed a novel DIO model that allowed for demonstration of FGF2:FGFR1 signaling as a key molecular mechanism connecting obesity to breakage of systemic tumor dormancy and metastatic progression.

Keyphrases

metastatic breast cancer
insulin resistance
metabolic syndrome
weight loss
type diabetes
high fat diet induced
weight gain
squamous cell carcinoma
small cell lung cancer
pulmonary hypertension
adipose tissue
skeletal muscle
body mass index