Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer.
Trasias MukamaRenée Turzanski FortnerVerena KatzkeLucas Cory HynesAgnese PetreraStefanie M HauckTheron JohnsonMatthias SchulzeCatarina SchibornAgnetha Linn Rostgaard-HansenAnne TjønnelandKim OvervadMaría José Sánchez PérezMarta Crous-BouMaría-Dolores ChirlaquePilar AmianoEva ArdanazEleanor L WattsRuth C TravisCarlotta SacerdoteSara GrioniGiovanna MasalaSimona SignorielloRosario TuminoInger T GramTorkjel M SandangerHanna SartorEva LundinAnnika IdahlAlicia K HeathLaure DossusElisabete WeiderpassRudolf KaaksPublished in: British journal of cancer (2022)
Using pre-diagnostic serum samples, this study identified markers with good discrimination for the lag-time of 0-9 months. However, the discrimination was low in blood samples collected more than 9 months prior to diagnosis, and none of the markers showed major improvement in discrimination when added to CA125.
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