Impact of benznidazole treatment on the functional response of Trypanosoma cruzi antigen-specific CD4+CD8+ T cells in chronic Chagas disease patients.

Elena Pérez-AntónAdriana EguiM Carmen ThomasConcepción J PuertaJohn Mario GonzálezAdriana CuéllarManuel SegoviaManuel Carlos López

Published in: PLoS neglected tropical diseases (2018)

CD4+CD8+ T cells could play an important role in the control of T. cruzi infection since they were able to produce effector molecules for parasite control. Benznidazole treatment partially reversed the exhaustion process caused by T. cruzi infection in these cells with an improvement in the functional response of the T. cruzi antigen-specific CD4+CD8+ T cells.

Keyphrases

trypanosoma cruzi
end stage renal disease
ejection fraction
chronic kidney disease
induced apoptosis
newly diagnosed
prognostic factors
oxidative stress
combination therapy
regulatory t cells
endoplasmic reticulum stress
patient reported outcomes
signaling pathway
replacement therapy